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2型糖尿病病程及胰岛素抵抗、胰岛β细胞功能损害与中医病机、证型演变相关性研究进展
引用本文:周洁,王纯庠. 2型糖尿病病程及胰岛素抵抗、胰岛β细胞功能损害与中医病机、证型演变相关性研究进展[J]. 长春中医药大学学报, 2014, 0(4): 754-756
作者姓名:周洁  王纯庠
作者单位:南京中医药大学;南京中医药大学附属苏州中医医院;
基金项目:苏州市科技计划项目“中医证型演变与2型糖尿病病程及胰岛素抵抗、胰岛β细胞功能损害的相关性临床研究”(SYS201260)
摘    要:检测空腹胰岛素、空腹血糖用以计算胰岛素抵抗指数、胰岛素敏感指数、胰岛素分泌指数,并运用这些客观指标指导中医临床辨证分型。目前已有研究显示,中医证型与胰岛素抵抗、胰岛β细胞功能有一定的相关性,将HOMA指数作为2型糖尿病分型的客观参考指标,随着2型糖尿病病程的延长、中医证型的演变,胰岛素抵抗持续存在并逐渐加重,胰岛β细胞分泌功能进行性衰减。明确2型糖尿病病程及胰岛素抵抗、胰岛β细胞功能损害与中医病机、证型的对应关系,能更好的指导临床辨证施治。

关 键 词:2型糖尿病  胰岛素抵抗  胰岛β细胞  中医证型

The correlation among course of the disease,insulin resistance,the function of pancreatic islet and TCM pathogenesis,syndromes in patients with T2DM
Affiliation:ZHOU Jie, WANG Chunxiang ( 1. Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China; 2. Suzhou Hospital of Traditional Chinese Medicine, Suzhou 215000, Jiangsu Province, China)
Abstract:HOMA-IR, ISI and HOMA-β, which could be obtained by fast insulin and fast glucose, could provide guidance for clinical dialectical pattern of TCM. Currently, some results indicate: Correlation between the syndrome of TCM of Type 2 diabetes mellitus and insulin resistance and islet β cells function definitely exist. HOMA index can be served as foundation of the differentiation of syndromes for Type 2 diabetes mellitus. With the course of Type 2 diabetes mellitus, the evolution of the TCM syndromes type, insulin resistance is aggravated continuously, and islet β cells function goes on decaying. Identify the correlation among course of the disease, insulin resistance, islet β cells function and TCM pathogenesis, syndromes in patients with Type 2 diabetes mellitus can promote the progress of TCM and strengthen practical guidance to distinction and treatment.
Keywords:type 2 diabetes  insulin resistance  pancreatic isletβ  TCM syndromes
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