| 不同分化程度鼻咽癌细胞化疗药物作用后放射敏感性的变化 |
| |
| 引用本文： | 卜俊国,张积仁,肖明星.不同分化程度鼻咽癌细胞化疗药物作用后放射敏感性的变化[J].南方医科大学学报,2006,26(8):1140-1142. |
| |
| 作者姓名： | 卜俊国 张积仁 肖明星 |
| |
| 作者单位： | 南方医科大学珠江医院肿瘤中心,广东,广州,510282 |
| |
| 摘 要： | 目的 检测鼻咽高分化鳞癌细胞系CNE1和低分化鳞癌细胞系CNE2细胞化疗药物作用后放射敏感性的变化。方法 对CNE1和CNE2细胞以及经阿霉素作用后的细胞射线照射，应用集落形成实验方法绘制细胞存活曲线，得出放射生物学参数，比较化疗药物作用后细胞放射敏感性的变化。结果 CNE1细胞化疗药物作用后放射敏感性增高；而CNE2细胞化疗药物作用后放射敏感性降低。结论临床上对中晚期鼻咽癌的治疗应根据其不同病理类型考虑个体化治疗方案。
|
| 关 键 词： | 鼻咽肿瘤 肿瘤细胞 培养的 放射治疗 化学治疗 放射敏感性 |
| 文章编号： | 1673-4254（2006）08-1140-03 |
| 收稿时间： | 2005-12-20 |
| 修稿时间： | 2005年12月20 |
Radiosensitivity changes of nasopharyngeal carcinoma cells with different levels of differentiation after treatment with chemotherapeutic agents |
| |
| BU Jun-guo,ZHANG Ji-ren,XIAO Ming-xing.Radiosensitivity changes of nasopharyngeal carcinoma cells with different levels of differentiation after treatment with chemotherapeutic agents[J].Journal of Southern Medical University,2006,26(8):1140-1142. |
| |
| Authors: | BU Jun-guo ZHANG Ji-ren XIAO Ming-xing |
| |
| Abstract: | Objective To examine the changes of radiosensitivity of CNE1, a well differentiated squamous cell line of nasopharyngeal carcinoma (NPC), and CNE2, a poorly differentiated squamous cell line of NPC, after treatment with chemotherapeutic agents. Methods CNE1 and CNE2 cells with and without treated by adriamycin (ADM) were irradiated by X-ray and the radiosensitivity changes of ADM-treated cells were analyzed according to the cell survival curve generated by colony formation assay. Result and Conclusion Radiosensitivity of CNE1 cells increased after ADM treatment, but that of CNE2 cells decreased, suggesting that different treatment regimens should be planned for advanced squamous cell NPC of different pathological types. |
| |
| Keywords: | nasopharyngeal carcinoma tumor cells cultured radiotherapy chemotherapy radiosensitivity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
