Cerebrospinal fluid 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline |
| |
Authors: | Malcolm B Bowers Jr |
| |
Institution: | (1) Department of Psychiatry and The Connecticut Mental Health Center, Yale University, New Haven, Connecticut, USA |
| |
Abstract: | Lumbar cerebrospinal fluid 5-HIAA, HVA, and the ratio 5-HIAA/HVA were measured followed probenecid administration in eleven patints with unipolar depression before and during treatment with amitriptyline (AMI). Control values were obtained from a group of inmate volunteers. Prior to treatment CSF 5HIAA formation in the depressives was not different from controls. During treatment with AMI, CSF 5-HIAA formation decreased. One patient with psychotic symptoms prior to AMI and two patients who developed psychotic reactions on AMI showed relatively low CSF 5HIAA formation prior to antidepressant therapy. Compared to controls CSF HVA values were higher in the depressives prior to AMI therapy. |
| |
Keywords: | Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid Homovanillic Acid Depression Amitriptyline Probenecid |
本文献已被 SpringerLink 等数据库收录! |
|