Synthesis and antimicrobial activity of hydroxy-isophthalaldehyde acid derivatives |
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| Authors: | E Piscopo M V Diurno O Mazzoni G Cirino A Bolognese |
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| Institution: | Departimento di Chimica Farmaceutica e Tossicologica Università di Napoli Federico II, Italy. |
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| Abstract: | 4-hydroxy-isophthalaldehyde acid (1), its alkyl esters (methyl, ethyl, propyl and butyl) and alkyl ethers (propyl, butyl, pentyl and esyl), as well as 6-hydroxy-isophthalaldehyde acid (2) ita alkyl esters (methyl and ethyl), 4-hydroxy-5-iodo-isophthalaldehyde acid (3) and its methyl ester were synthesized and characterized. Antimicrobial and antifungal activity was tested and the LD50 of the most active compound 4 was determined. |
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