非恶性疟人体疟原虫药物抗性分子标记研究进展

随着抗疟药的长期、广泛使用，疟原虫对抗疟药逐渐产生抗性。目前有关恶性疟原虫的抗药性分子标记研究较多，而对非恶性疟原虫关注度相对较小。为了更好地为临床治疗的合理用药提供科学依据，为非恶性疟人体疟原虫对抗疟药敏感性分子监测提供参考，本文就非恶性疟人体疟原虫常见抗药性相关分子标记的研究进展作一综述。

Progress in researches on molecular markers of non-Plasmodium falciparum drug resistance

With the long?term and widespread application of antimalarial drugs， Plasmodium falciparum has gradually produced resistance to antimalarial drugs. At present， there are more researches on the molecular markers of P. falciparum drug resistance， while less attention has been paid to the molecular markers of non?P. falciparum drug resistance. In order to provide the reference for rational drug use in clinical treatment and reference for molecular monitoring of antimalarial drug sensitivity of non?P. falciparum， this paper reviews the researches on the common molecular markers related to non?P. falciparum drug resistance.