洛美沙星静脉滴注致严重肝损害

1例44岁女性患者,因急性咽炎静脉滴注洛美沙星0.2 g加入5%葡萄糖注射液250 ml,2次/d。治疗2 d后患者出现乏力、多汗。肝功能检查:丙氨酸转氨酶(ALT)1076 U/L,天冬氨酸转氨酶(AST)653 U/L,总胆红素(TBil)43.1μmol/L,直接胆红素(DBil)32.3μmol/L。诊断:急性肝损害。立即停用洛美沙星,给予保肝药物。停药第4天患者症状好转,但出现巩膜及皮肤黄染。复查肝功能:ALT 731 U/L,AST 420 U/L,TBil 164.8μmol/L,DBil 122.9μmol/L。14 d后患者黄染消退,肝功能恢复正常。

Severe liver damage following intravenous infusions of lomefloxacin

A 44-year-old woman with acute pharyngitis received an IV infusion of lomefloxacin 0.2 g dissolved in glucose 250 ml twice daily.After 2 days of treatment,she experienced asthenia and hyperhidrosis.Liver function tests showed the following levels： ALT 1076 U/L,AST 653 U/L,TBil 43.1 μmol/L,and DBil 32.3 μmol/L.She was diagnosed with acute liver damage.Lomefloxacin was discontinued immediately and she was given drugs for liver protection treatment.Four days after discontinuation of the drug,the patient＇s symptoms improved,but she presented with jaundiced sclera and skin.Repeat liver function tests revealed the following levels： ALT 731 U/L,AST 420 U/L,TBil 164.8 μmol/L,and DBil 122.9 μmol/L.Fourteen days later,her jaundice subsided and her liver function returned to normal range.