辛伐他汀致横纹肌溶解症

1例57岁男性患者因急性心肌梗死行冠状动脉支架置入术。术后给予阿司匹林100 mg,1次/d口服;氯吡格雷75 mg,1次/d口服;辛伐他汀40 mg,1次/d睡前口服。第5天患者出现右下肢酸痛。第8天肌酸激酶2085 U/L,血清肌酐187μmol/L,同时出现尿色加深,尿潜血(+)。停用辛伐他汀,继续使用阿司匹林及氯吡格雷,同时给予辅酶Q10口服。停药第2天患者右下肢酸痛症状明显缓解,肌酸激酶1337 U/L。停药第11天,其肌酸激酶降至186 U/L,血清肌酐101μmol/L,遂出院。

Simvastatin-induced rhabdomyolysis

A 57-year-old man with acute myocardial infarction underwent coronary artery stenting.After the surgery,he was given aspirin 100 mg once daily,clopodigrel 75 mg once daily,and simvastatin 40 mg once daily at bedtime.On day 5,he developed aching pain in his right lower limb.On day 8,his creatine kinase was 2085 U/L and serum creatine was 187 μmol/L.Meanwhile he experienced dark urine and occult blood（＋）.Simvastatin was withdrawn,aspirin and clopodigrel were continued,and coenzyme Q10 was administered.On day 2 of drug discontinuation,his aching pain in his right lower limb improved markedly and creatine kinase level was 1337 U/L.On day 11 of drug discontinuation,his creatine kinase level decreased to 186 U/L and his serum creatine level was 101 μmol/L,and then he was discharged.