Nuclear magnetic resonance spectroscopic studies of the interaction of methyl methacrylate and ethylene dimethacrylate with phosphatidylcholine liposomes as a model for biomembranes |
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| Authors: | S Fujisawa Y Kadoma Y Komoda |
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| Affiliation: | School of Dentistry, Tokyo Medical and Dental University, Japan. |
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| Abstract: | The interaction of methyl methacrylate (MMA) and ethylene dimethacrylate (EDMA) with dipalmitoyl phosphatidylcholine (DPPC) liposomes was studied by 1H and 13C nuclear magnetic resonance spectroscopy (NMR). It was found that the changes in the 1H chemical shift of EDMA were larger than those of MMA when comparing membrane-bound state with free state and that the amount of EDMA incorporated into DPPC liposomes was approximately 74%, whilst MMA was approximately 41%. The major changes in chemical shifts of EDMA appeared to be due to its interaction with the acyl chains of DPPC liposomes. |
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