Effect of oxidized cholesterol derivatives on lymphokine-stimulated macrophage differentiation and primary allogenic mixed culture of human lymphocytes |
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| Authors: | M I Musatov M I Dushkin N N Vol'skii O M Perminova V I Konenkov V A Kozlov |
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| Institution: | (1) Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk;(2) Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk |
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| Abstract: | Products of cholesterol oxidation, 25-hydroxycholesterol and 7-ketocholesterol, in a dose of 1 μg/ml considerably suppress
proliferative response in a primary one-way mixed culture of human lymphocytes and have no effect on spontaneous proliferation.
Preliminary 18-h separate culturing of the stimulator and responders with these lipids shows that inhibiting effect of these
lipids on cell proliferation is associated with their influence on both stimulator and, to a greater extent, responders. Both
lipids in the same dose inhibit accumulation of HLA-DR-positive macrophages in a 4-day culture of peripheral blood adherent
cells stimulated with lymphokine-containing supernatant.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 655–657, December, 1997 |
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| Keywords: | oxidized cholesterol macrophages HLA-DR expression mixed lymphocyte culture |
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