牡丹江地区汉族人群原发性高血压遗传特征分析 |
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引用本文: | 宋洁,李承威.牡丹江地区汉族人群原发性高血压遗传特征分析[J].牡丹江医学院学报,2013,34(3):7-10. |
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作者姓名: | 宋洁 李承威 |
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作者单位: | 宋洁 (牡丹江医学院生物教研室,黑龙江,牡丹江,157011); 李承威 (牡丹江医学院生物教研室,黑龙江,牡丹江,157011); |
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基金项目: | 黑龙江省卫生厅课题(项目编号:2012-286)黑龙江省研究生创新科研课题(项目编号:YJSCX2012-379HLJ) |
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摘 要: | 目的:分析黑龙江省牡丹江地区汉族居民原发性高血压的遗传特征,为预防和干预高纬地区原发性高血压提供参考依据。方法:采用病例对照研究方法对394例原发性高血压患者及同期体检的300名非高血压健康人群进行问卷调查。结果:汉族原发性高血压患者遗传度为61.1%,其中男57.6%,女65.8%;病例组家系一级亲属、家系男性一级亲属和家系女性一级亲属的患病率分别为37.39%、30.07%和43.25%,均高于对照组的9.65%、9.92%和11.24%,差异有统计学意义(P〈0.05);原发性高血压患者分离比为0.22(分离比〈0.25)。结论:牡丹江地区汉族人群的原发性高血压符合多基因遗传病特征。
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关 键 词: | 原发性高血压 遗传特征 汉族 |
GENETIC CHARACTERISTICS OF ESSENTIAL HYPERTENSION AMONG HAN POPULATION IN MUDANJIAN AREA |
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Institution: | Song Jie et al(Department of Biology,Mudanjiang Medical University,MuDanJiang 157011,China) |
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Abstract: | Objective: To study genetic characteristics of essential Hypertension in Han Population in MuDanJiang area,it provides references for the prevention and intervention of essential hypertension in high latitude area.Methods: Case-control method was adopted in this study.A questionnaire survey was conducted in patients and healthy people,394 patients were diagnosed with essential hypertension and 300 healthy peoplewithout hypertension.conducted physical examinationResults: Heritability of essential hypertension was 61.1%,male 57.6%,female 65.8%;The prevalence rate of family first-degree relatives was 37.39 %,male was 30.07% female was 43.25% in case group family.It is more than control group family 9.65% 、9.92% 和 11.24%.The separation ratio of EH is 0.22.Conclusion: The prevalence of EH display an hereditary tendency and it shows a polygenic inheritance mode. |
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Keywords: | Genetic Characteristics Essential Hypertension Han Population |
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