牡丹江地区汉族人群原发性高血压遗传特征分析

目的：分析黑龙江省牡丹江地区汉族居民原发性高血压的遗传特征,为预防和干预高纬地区原发性高血压提供参考依据。方法：采用病例对照研究方法对394例原发性高血压患者及同期体检的300名非高血压健康人群进行问卷调查。结果：汉族原发性高血压患者遗传度为61.1%,其中男57.6%,女65.8%;病例组家系一级亲属、家系男性一级亲属和家系女性一级亲属的患病率分别为37.39%、30.07%和43.25%,均高于对照组的9.65%、9.92%和11.24%,差异有统计学意义（P〈0.05）;原发性高血压患者分离比为0.22（分离比〈0.25）。结论：牡丹江地区汉族人群的原发性高血压符合多基因遗传病特征。

GENETIC CHARACTERISTICS OF ESSENTIAL HYPERTENSION AMONG HAN POPULATION IN MUDANJIAN AREA

Objective： To study genetic characteristics of essential Hypertension in Han Population in MuDanJiang area,it provides references for the prevention and intervention of essential hypertension in high latitude area.Methods： Case-control method was adopted in this study.A questionnaire survey was conducted in patients and healthy people,394 patients were diagnosed with essential hypertension and 300 healthy peoplewithout hypertension.conducted physical examinationResults： Heritability of essential hypertension was 61.1%,male 57.6%,female 65.8%;The prevalence rate of family first-degree relatives was 37.39 %,male was 30.07% female was 43.25% in case group family.It is more than control group family 9.65% 、9.92% 和 11.24%.The separation ratio of EH is 0.22.Conclusion： The prevalence of EH display an hereditary tendency and it shows a polygenic inheritance mode.