| 某些异喹啉类生物碱对大鼠脑内单胺的影响 |
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| 引用本文： | 刘国卿,蒋莹,彭光,依布哈依木,周乐泉. 某些异喹啉类生物碱对大鼠脑内单胺的影响[J]. 药学学报, 1985, 0(8) |
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| 作者姓名： | 刘国卿 蒋莹 彭光 依布哈依木 周乐泉 |
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| 作者单位： | 南京药学院药理教研室(刘国卿，蒋莹，彭光，依布哈依木)，南京药学院药理教研室(周乐泉) |
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| 摘 要： | 1-四氢巴马汀(1-THP)和四氢小檗碱(THB)与dl-THP一样都能降低脑内单胺和升高酸性代谢产物DOPAC,HVA和5-HIAA。它们作用的强弱次序为dl-THP<1-THP
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| 关 键 词： | 异喹啉类生物碱 单胺 纹状体 边缘区 |
EFFECT OF SOME ISOQUINOLINE ALKALOIDS ON MONOAMINES IN RAT BRAIN |
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| LIU Guo-Qing,JIANG Ying,PENG Guang,IBRAHIM and ZHOU Le-Quan. EFFECT OF SOME ISOQUINOLINE ALKALOIDS ON MONOAMINES IN RAT BRAIN[J]. Acta pharmaceutica Sinica, 1985, 0(8) |
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| Authors: | LIU Guo-Qing JIANG Ying PENG Guang IBRAHIM ZHOU Le-Quan |
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| Abstract: | Investigation of some isoquinoline alkaloids on monoamine metabolism in rat brain was conducted using HPLC-electrochemical detection. It was found that 1-tetrahydropalmatine (1-THP) and dl-tetrahydroberberine (dl-THB), 60 mg/kg ip, like dl-THP, a known short-term monoamine depletor, lowered monoamines and raised acidic metabolites (DOPAC, HVA and 5-HIAA) in the striatum and limbic area. But, the effect of dl-THP was much stronger than that of 1-THP. This may mean that d-THP is more active than 1-THP. The potency of dl-THB was found to be the weakest of the three alkaloids, dl-Tetrahydrocoptisine and dl-tetrahydrojatrorrhizine induced a slight reduction of dopamine only in the limbic area. However, both alkaloids markedly increased acidic motabolites in the striatum and limbic area. No significant changes on monoamines in rat brain was produced by berbamine, palmatine chloride, berberine chloride and 13-methylberberine iodide at doses of 60 mg/kg 30 min after intraperitoneal injection. |
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| Keywords: | Isoquinoline alkaloids Monoamines Striatum Limbic area |
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