联合检测抗CCP抗体、AKA与GPI在类风湿性关节炎诊断中的应用

目的探讨抗环瓜氨酸多肽（anti-cyclic citrullinated peptide,anti-CCP）抗体、抗角蛋白抗体（anti-keratinantibody,AKA）和葡萄糖6-磷酸异构酶（glucose-6-phosphate isomerase,GPI）联合检测在诊断类风湿性关节炎（rheumatoid arthritis,RA）中的价值。方法对58例RA患者、60例非RA患者及50例健康正常人进行3项检测,并进行比较分析。结果RA患者的3项检测指标阳性率均明显高于非RA患者和正常健康者,差异有统计学意义（P〈0.01）,3项指标单独检测对RA诊断的敏感性依次为anti-CCP抗体〉GPI〉AKA,特异性依次为AKA〉抗CCP抗体〉GPI;联合检测对RA诊断的敏感性下降,特异性却升高甚至达到100%。结论联合检测可提高诊断特异性,有利于临床确诊。

Joint Detection of Anti-CCP Antibody, AKA and GPI in Diagnosis of Rheumatic Arthtitis

Objective To assess the value of joint detection of anti-cyclic citrullinated peptide（anti-CCP）,antibody anti-keratin antibody（AKA）and glucose-6-phosphate isomerase（GPI）for diagnosis of rheumatoid arthritis（RA）.Methods Fifty-eight RA patients,60 non-RA patients and 50 healthy people were studied.Results The positive rates of three antibodies in RA patients were significantly higher than non-RA patients and normal healthy people（P〈0.005）.For RA diagnosis the sensitivity of anti-CCP antibody〉 AKA 〉GPI, and the specificity of AKA 〉 anti-CCP antibody GPI. The sensitivity to RF diagnosis of their joint detection decreased but the specificity increased （100K）. Conclusion Joint detection can improve diagnostic specificity and is helpful in clinic.