Antagonism of Myc functions by Arf |
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| Authors: | Cleveland John L Sherr Charles J |
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| Affiliation: | Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. |
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| Abstract: | The Arf-Mdm2-p53 tumor suppressor pathway is activated by sustained hyperproliferative signals emanating from oncoproteins such as Myc. A recent study reveals a novel level of feedback control, whereby induced p19(Arf) binds to Myc and blocks cell proliferation by selectively impairing its transactivation functions. |
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