局部振动对家兔血清单胺类神经递质的影响

目的探讨振动对外周单胺类神经递质的影响,研究振动性神经损伤机制。方法将24只新西兰家兔随机分为低接振强度组[接振强度为ahw(4)3.03 m/s2]、中接振强度组[接振强度为ahw(4)6.13 m/s2]、高接振强度组[接振强度ahw(4)12.25 m/s2]和无接振对照组,用液相色谱-电化学检测法测定血清中单胺类神经递质:去甲肾上腺素(noradrenalin,NE)、5-羟色胺(5-serotonin,5-HT)和多巴胺(dopamine,DA)。结果振动中、高接振强度组血清中NE、5-HT和DA在接振不同时间,与相同时间段的对照组比较,均有明显升高(P<0.01),与同组接振前比较,也有明显升高(P<0.01)。总体上,随实验时间延长和接振强度增大,NE、5-HT和DA有升高趋势。结论振动可引起单胺类神经递质升高,可能参与振动性神经损伤机制。。

Effects of Local Vibration on Serum Monoamine Neuro-transmitters of Rabbits

Objective To investigate the effects of local vibration on serum monoamine neuro-transmitters and the correlation with vibration-induced neural impairment.Methods Rabbits were divided into 4 groups at random.One was the control group and the other three groups[A group with the ahw(4)3.03 m/s2,B group with the ahw(4)6.13 m/s2,C group with the ahw(4)12.25 m/s2]were tested at different levels of low,medium and high vibration power.Serum monoamine neuro-transmitters were measured in each group.Results With the increase of vibration power,the concentration of serum noradrenalin(NE),5-serotonin(5-HT)and dopamine(DA)had a tendency to significantly increase.Conclusions The local vibration may cause the changes of serum monoamine neuro-transmitters.The changes are related to vibration-induced neural impairment.