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Very close linkage between D2S1 and ACP1 on chromosome 2p |
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| Authors: | R A LOTHE T GEDDE-DAHL B OLAISEN† E BAKKERS‡ P PEARSON‡ |
| Institution: | *Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo 3, Norway;†Institute of Forensic Medicine, University of Oslo, Rikshospitalet, Oslo 1, Norway;‡Department of Human Genetics, University of Leiden, Holland |
| Abstract: | The genomic DNA-probe L2.30 was used to assign D2S1 to 2p23–pter by in situ hybridization. The RFLP revealed by Bgl II was then used for linkage studies in the Oslo-NHIK families segregating for the acid phosphatase ACPl protein polymorphism. Evidence for very close linkage was found by a lod score of +17.17 at recombination fraction θ = 001. By this close linkage 92 informative meioses could be inferred from the families and with only a single crossover. The upper probability limit to the recombination fraction is 006 according to the HGM 8 criterion. No association between ACP1 alleles and D2S1 Bgl II alleles was found. The Norwegian gene frequencies for 0251 were A1 (9–0 kb) = 065 and A2 (6.3 kb) = 0.35. |
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