临床药动学给药个体化系统的研制及应用

 目的：为利用临床常规监测的血药浓度数据估算病人的个体药动学参数，优化给药方案，设计、研制了临床药动学给药个体化系统（CPKDP程序）。方法：依据群体药动学原理及Bayes公式，CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发，在希望汉字系统UCDOS 5.0平台上运行。结果：CPKDP程序适用于具有不同药动学特征的多种药物，适用于不同给药途径的单剂量或多剂量给药。在群体药动学参数的基础上，结合病人个体特征，以1，2血药浓度作为反馈，即可拟合估算个体药动学参数，优化给药方案。结论：经初步应用，CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具。

Development and application clinical pharmacokinetics and individualizing dosage regimens system

OBJECTIVE: To design and develop a clinical pharmacokinetics and individual drug dosage regimens system (CPKDP program) for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS: According to the principle of population pharmacokinetics and Bayes' formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS: CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient's pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION: CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.