An evolutionary analysis of trypanosomatid GP63 proteases |
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| Authors: | Ma Lina Chen Kaifu Meng Qingshu Liu Qingyou Tang Petrus Hu Songnian Yu Jun |
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| Affiliation: | (1) CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road, , Chaoyang District, , Beijing, 100029, People’s Republic of China;(2) Graduate University, Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China;(3) Molecular Regulation and Bioinformatics Laboratory, Chang Gung University, Taoyuan, 333, Taiwan;(4) Animal Reproduction Institute, Guangxi Key Laboratory of Subtropical Bioresource Conservation and Utilization, Guangxi University, Nanning, 530004, People’s Republic of China; |
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| Abstract: | The trypanosomatid GP63 proteases are known to be involved in parasite–host interaction and exhibit strong sequence and structural similarities to those of their hosts and insect vectors. Based on genome sequences of the three trypanosomatids, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp., we annotated all their GP63 proteases and divided highly duplicated T. cruzi GP63 proteases into four novel groups according to sequence features. In Leishmania spp., we studied the evolutionary dynamics of GP63 proteins and identified 57 amino acid sites that are under significant positive selections. These sites may contribute to the functional variations of the GP63 proteases and provide clues for vaccine development. |
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