局部晚期鼻咽癌放疗与化疗综合治疗的临床分析

目的：分析放疗与化疗综合治疗局部晚期鼻咽癌临床疗效及安全性。方法将180例鼻咽癌患者随机均分为观察组和对照组，观察组采用同步放化疗和辅助化疗方案治疗，对照组采用单纯放疗方案治疗。结果观察组和对照组3年的局部区域无复发生存率、无远处转移生存率及总生存率分别为88.89%、95.56%、100.0%和71.11%、83.33%、67.78%，两组以上指标比较差异均具有统计学意义。治疗期间，观察组恶心呕吐及白细胞减少症的发生率显著高于对照组；治疗后1年，两组主要毒副反应的发生率无显著性差异。结论采用同期放化疗辅助化疗可显著提高局部晚期鼻咽癌患者的远期生存率，虽然其急性毒性发生率较单纯放疗高，但其远期毒性与单纯放疗相当。

Clinical analysis of radiotherapy and chemotherapy in locally advanced comprehensive treatment

Objective To analyze and evaluate the efficacy and safety of concurrent chemoradiotherapy and adjuvant chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma. Methods 90 patients with locoregionally advanced nasopharyngeal carcinoma were randomly assigned to observation group and control group, patients of the two group received either concurrent ehemoradiotherapy and adjuvant chemotherapy（CCRT） or radiotherapy alone（RT）. Results The 3-years local regionalrecurrent-free, distant metastasis-free, and overall survival rate of observation group and control group had statistical significance. The observation group had significantly more toxicities than the control group, including leucopenia, emesis and mueositls. The late toxieities were similar for both group. Conclusion CCRT is superior to RT alone in increasing the distant survival. Although there is significantly increase in major acute toxicity, but no statistically significant increase in major late toxicity.