临床检验量值溯源与参考系统

医疗卫生工作需要准确可比的检验结果，实现临床检验标准化的有效途径是建立和保证检验结果的计量学溯源性。溯源性通过一系列由不同等级测量程序和校准物实现的比较测量而建立，较低级别程序足够特异和校准物具有互通性是计量学溯源的前提。较高级别的测量程序和校准物称参考系统，参考系统需符合特定计量学要求，为此有关国际组织成立检验医学溯源联合委员会（JCTLM），鉴定现有国际参考测量程序、参考物质和参考实验室。总之，临床检验量值溯源问题已受到广泛重视，发展和应用参考系统将可能成为临床检验领域的重要课题。

Metrological traceability and reference systems in laboratory medicine

In laboratory medicine, accurate and comparable measurement results are required for correct medical interpretations.Metrological traceability is an important approach to achieve standardization of test results obtained with different analytic systems.Traceability is established by a series of comparative measurements using a hierarchy measurement procedures and calibrators.Specificity of the lower order methods and commutability of the calibrators are the prerequisites in establishing traceability.The higher order procedures and calibrators in the hierarchy are called reference systems and it is important that the reference systems are metrologically qualified.The Joint Committee for Traceability in Laboratory Medicine (JCTLM) has been formed to identify the reference systems worldwide.In conclusion, the concept of metrological traceability has been introduced to the filed of laboratory medicine.Development and implementation of reference systems in laboratory medicine are expected.