The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis |
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Authors: | Liu Xin Kruger Peter S Weiss Michael Roberts Michael S |
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Institution: | Therapeutics Research Centre, School of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia. |
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Abstract: | AIMTo characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of cisatracurium in critically ill patients with severe sepsis.METHODSBlood samples were collected before and over 8 h after a single bolus dose of cisatracurium 0.1 mg kg?1. Neuromuscular block was assessed by accelerometric peripheral nerve stimulation (TOF Watch). Plasma concentration and neuromuscular block data were fitted using population analysis.RESULTSSteady-state volume of distribution was determined to be 111 ± 71 ml kg?1 and plasma clearance was 5.2 ± 1.8 ml min?1 kg?1 in these patients with greater inter-patient variability compared with other populations. The time to maximum block (8.3 ± 2.9 min) and delay time of transferring from central to effect compartment (17.2 min) was much longer, while the maximum block (95.0 ± 6.3%) was less compared with those in other patient populations. The effect compartment concentration resulting in 50% of maximum effect (128 ± 58 ng ml?1) was larger than previously described.CONCLUSIONSThis study suggests that standard dosing of cisatracurium in patients with severe sepsis results in a slower patient response with a reduced effect. Use of a larger dose may overcome this reduced delayed response. |
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Keywords: | cisatracurium intensive care pharmacodynamics pharmacokinetics |
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