丹蛭降糖胶囊对实验性糖尿病大鼠降糖作用

目的:观察丹蛭降糖胶囊对实验性糖尿病大鼠的降糖作用.方法:大鼠静脉注射链脲佐菌素致实验性糖尿病模型,随机分为模型组、盐酸苯乙双胍组(75 mg·kg-1)、糖脉康组(1.5 g·kg-1)和丹蛭降糖胶囊高、中、低剂量组(生药13,6.5,3.2 g·kg-1),每组8只,另选8只正常大鼠为正常对照组,给药20 d后,观察各组大鼠体重、血糖、糖耐量、糖化血红蛋白及胰岛素水平的变化.结果:丹蛭降糖胶囊高剂量组能显著降低糖尿病大鼠空腹血糖(P＜0.01),改善糖耐量(P＜0.01);各剂量组均能显著增加糖尿病大鼠的体重(P＜0.01,P＜0.01,P＜0.05)、降低糖化血红蛋白水平(P＜0.01,P＜0.01,P＜0.01);而不影响胰岛素水平.结论:丹蛭降糖胶囊对实验性糖尿病大鼠有显著降糖作用.

Anti-diabetic Effects of Danzhi Jiangtang Capsule on Experimental Diabetic Rats

Objective: To investigate the anti-diabetic effect of Danzhi Jiangtang capsule (DJC) on experimental diabetic rats. Method: Experimental diabetic model in rats was induced by the injection of streptozocin. The models were divided randomly into 6 groups:model group (normal saline ig), phenformin hydrochloride group (75 mg·kg^-1, ig), Tangmaikang group (1.5 g·kg^-1, ig) and DJC low, middle, high dose (13, 6.5, 3.2 g·kg^-1,ig) groups (n=8 each). Rats were selected as normal group (nomal saline ig). After 20 days of administration, effects of body weight, blood glucose, glucose tolerance and insulin level of rats were observed. Result: The DJC high dose group could significantly decrease level of fasting blood glucose (P<0.01) and improve glucose tolerance (P<0.01). All the DJC groups could significantly increase body weight of diabetic rats (P<0.01, P<0.05) and decrease level of glycosylated serum protein (P<0.01). No obvious effect of DJC on insulin level. Conclusion: DJC has significant anti-diabetic effect on experimental diabetic rats.