| RP-HPLC测定羟苯磺酸钙含量及有关物质 |
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| 引用本文： | 于梦,刘文乔,高瑞芳,王忠元,赵怀清. RP-HPLC测定羟苯磺酸钙含量及有关物质[J]. 中国实验方剂学杂志, 2013, 19(17): 152-156 |
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| 作者姓名： | 于梦 刘文乔 高瑞芳 王忠元 赵怀清 |
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| 作者单位： | 沈阳药科大学药学院,沈阳,110016 |
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| 摘 要： | 目的:建立反相高效液相色谱法测定羟苯磺酸钙原料药的含量及其有关物质.方法:采用C8色谱柱(4.6 mm×200 mm,5μm),柱温35℃,50 mmol·L-1磷酸二氢钠溶液-乙腈(90∶ 10)为流动相等度洗脱,流速0.8 mL·min-1,检测波长220 nm,进样体积20 μL.结果:含量测定色谱条件下,羟苯磺酸钙质量浓度在20.0 ～ 200.0 mg·L-1与峰面积呈良好的线性关系(r=0.999 5),平均回收率99.4％;有关物质项下杂质氢醌的含量分别为0.018％,0.023％,0.021％,杂质总量分别为0.16％,0.18％,0.13％.结论:方法简便、快速,可用于羟苯磺酸钙原料药的含量测定及有关物质的检查.
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| 关 键 词： | 羟苯磺酸钙 氢醌 有关物质 含量测定 反相高效液相色谱法 |
| 收稿时间： | 2012-11-23 |
Determination of Calcium Dobesilate and its Related Substances by RP-HPLC |
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| YU Meng,LIU Wen-qiao,GAO Rui-fang,WANG Zhong-yuan and ZHAO Huai-qing. Determination of Calcium Dobesilate and its Related Substances by RP-HPLC[J]. China Journal of Experimental Traditional Medical Formulae, 2013, 19(17): 152-156 |
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| Authors: | YU Meng LIU Wen-qiao GAO Rui-fang WANG Zhong-yuan ZHAO Huai-qing |
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| Affiliation: | School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | |
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| Keywords: | calcium dobesilate hydroquinone related substances content determination RP-HPLC |
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