Superior Efficacy of Liposomal Amphotericin B with Prolonged Circulation in Blood in the Treatment of Severe Candidiasis in Leukopenic Mice |
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| Authors: | Els W M van Etten Susan V Snijders Wim van Vianen and Irma A J M Bakker-Woudenberg |
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| Institution: | Department of Medical Microbiology and Infectious Diseases, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands |
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| Abstract: | In leukopenic mice with severe systemic candidiasis, single-dose treatment (5 mg of amphotericin B [AMB]/kg of body weight) with long-circulating polyethylene glycol-coated AMB liposomes (PEG-AMB-LIP) resulted in zero mortality and a significant reduction in the number of viable Candida albicans in the kidney, whereas 70% mortality was seen in mice treated with five daily doses of AmBisome (5 mg of AMB/kg · day). When the first of five daily doses of AmBisome was combined with a single low dose of Fungizone (0.1 mg of AMB/kg), the efficacy was equal to that of PEG-AMB-LIP. |
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