| 多西他赛联合顺铂和替加氟治疗进展期胃癌的临床分析 |
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| 引用本文： | 宋丽杰. 多西他赛联合顺铂和替加氟治疗进展期胃癌的临床分析[J]. 医药论坛杂志, 2009, 0(10): 21-22,25 |
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| 作者姓名： | 宋丽杰 |
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| 作者单位： | 郑州大学第一附属医院肿瘤科,郑州市,450052 |
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| 摘 要： | 目的观察多西他赛(DTX)联合顺铂(DDP)和替加氟(FT-207)对进展期胃癌的近期疗效和不良反应。方法对经病理学或细胞学确诊的24例进展期胃癌患者采用DTX 75mg/m2第1,8天ivgtt,DDP 20mg/m2第1~5天ivgtt,FT-207 500mg/m2第1~5天ivgtt方案化疗,21天为1周期,所有患者均接受至少2个周期治疗后评价疗效。结果全组病例均可评价疗效:CR 1例,PR 12例,SD 5例,PD 6例;近期客观有效率54.2%。其中初治15例,CR 1例,PR 7例,总有效率53.3%;复治患者为9例,CR 0例,PR 4例,总有效率44.4%。主要不良反应为骨髓抑制、恶心呕吐和脱发。结论DTX联合DDP和FT-207治疗进展期胃癌疗效肯定,不良反应轻,耐受性好,初治疗效优于复治,值得临床进一步扩大研究。
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| 关 键 词： | 进展期胃癌 多西他赛 顺铂 替加氟 |
Docetaxel Combined with Cisplatin and Tegafur in Treatment of Advanced Gastric Carcinoma |
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| SONG Lijie The First Hospital of Zhengzhou University,Zhengzhou ,China. Docetaxel Combined with Cisplatin and Tegafur in Treatment of Advanced Gastric Carcinoma[J]. Journal of Medical Forum, 2009, 0(10): 21-22,25 |
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| Authors: | SONG Lijie The First Hospital of Zhengzhou University Zhengzhou China |
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| Affiliation: | SONG Lijie The First Hospital of Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To evaluate the efficacy and toxicity of docetaxel(DTX) combined with cisplatin(DDP) and tegafur(FT-207) in treating patients with advanced gastric carcinoma.Methods Twenty-four patients with advanced gastric cancer diagnosed pathologically were enrolled into the study.The patients received DTX 75 mg/m 2 on d1 and d8,DDP 20mg/m 2 ivgtt on d1~5and FT-207 500mg/m 2 d1~5.The chemotherapy was repeated every 21 days.All the patients received at least 2 cycles.Results In the whole series(n=24),there was... |
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| Keywords: | Advanced gastric carcinoma Docetaxel Cisplatin Tegafur |
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