| Cloning and expression of the fusion protein of interleukin-2 and ESAT6 in Mycobacterium bovis Bacillus Calmette Guérin strain |
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| 作者姓名： | Fan XL Wang LM Lu XY Tu ZG Shi CH Xu ZK |
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| 作者单位： | Department of Pathogenic Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Microbiology, Fourth Military Medical University, Xi’an 710032, China;Department of Clinical Immunology, Chongqing University of Medical Science, Chongqing 400016, China;Department of Clinical Immunology, Chongqing University of Medical Science, Chongqing 400016, China;Department of Microbiology, Fourth Military Medical University, Xi’an 710032, China;Department of Microbiology, Fourth Military Medical University, Xi’an 710032, China |
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| 基金项目： | ThisworkwassupportedbygrantsfromNationalNaturalScienceFoundationofChina(No. 30170855 ) and863 ProjectProgram(No. 2001AA215201) |
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| 摘 要： | Tuberculosis(TB)isthemostcommoncauseofdeathininfectiousdiseases; itisestimatedthatapproximately2millionpeopleperyeardieofTB ThepresentavailableTBvaccineisaliveattenuatedstrain,MycobacteriumbovisBacillusCalmetteGuérin (BCG) However, ithasbeenshownthatBCGhasvariableprotectiveefficacy, rangingfrom 0 to85% indifferentclinicalexperiments 1 Therefore, anewTBvaccineisurgentlyneeded Manytrialshavebeendonetodevelopthesecond generationTBvaccinesinrecentyears; candidatesincludeavirulent, auxotro…
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| 关 键 词： | 溶解蛋白 基因表达 分子克隆 白介素-2 ESAT6 分支杆菌 细菌感染 |
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