VEGF与肿瘤的放射治疗

肿瘤的VEGF(血管内皮生长因子)表达与肿瘤的生长、侵袭、远处转移密切相关,它反映了接受放射治疗肿瘤的生物学和临床行为。回顾近年来的文献说明:(1)各种不同的肿瘤组织在放疗后均表现为VEGF水平上调。(2)肿瘤的高VEGF表达,提示该肿瘤对放射治疗不敏感,预示着疗效不佳。因此,通过拮抗VEGF表达,可以增强放疗疗效。测定VEGF含量可以评估肿瘤的新生血管生成,并据此对肿瘤进行分类,用于制定个性化放疗方案。

VEGF and radiation sensibitity

VEGF(vascular endothelial growth factor)is important for tumor growth,local invasion and the distant metasta-sis.It provides important information about the biology and the clinical behavior of tumors undergoing radiotherapy.This review summarizing the present study reports and suggests:(1)Irradiation can induce VEGF expression in diverse tumor cell types.(2)VEGF can be as a predictive factor of response to radiotherapy.VEGF increases in tumors will be resistant to radiation therapy.Anti-VEGF strategies can be used in combination with radiation therapy,and it can increase the anti-tu-mor effects of radiation therapy.A classification of tumors according to their VEGF level before therapy can be used into designed individual treatment planning.