健康老年男性脂肪负荷餐后雄激素水平的改变

 目的探讨健康老年男性富含三酰甘油脂蛋白(TRL)清除延迟与性激素水平改变的关系.方法与脂肪耐量试验同时采集空腹、脂肪负荷餐后(餐后)3 h、8 h静脉血.测定血浆三酰甘油(TG)、高密度脂蛋白-胆固醇(HDL-C)、总胆固醇(CHO)和血浆睾酮(T)、雌二醇(E2)、垂体泌乳素(PRL)、促黄体生成激素(LH)、促卵泡激素(FSH)动态变化水平.结果健康老年男性TRL清除延迟发生率7.8%.TRL清除延迟组较清除正常组基础T水平低、E2水平相对高(P＜0.01或P＜0.05).餐后高TG应答和(或)TRL清除延迟导致血浆T水平降低、E2水平升高(P＜0.01或P＜0.05),T/E2比值失衡.血浆PRL、LH、FSH改变差异无统计学意义(P＞0.05).结论 TRL清除延迟是致动脉粥样硬化的危险因素,也是导致健康老年男性T/E2比值失衡的直接原因,可能与动脉粥样硬化发生发展有关.

Changes in sex hormone levels after a fat loading meal in elderly healthy men

Objective To study the relationship between delayed clearance of triglyceride-rich lipoproteins(TRL) and sex hormones in elderly healthy men.Methods Blood samples were taken after a fat loading meal on an empty stomach,and 3 and 8 hours.Plasma triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),cholesterol(CHO),testosterone(T),estradiol(E_2),prolactin(PRL),luteinizing hormone(LH),and follicle-stimulating hormone(FSH) were determined for comparing their dynamic changes.Results The incidence of delayed clearance of TRL in healthy old men was 7.8%.Lower T and higher E_2 fasting levels were found in the delayed TRL clearance group,compared with the normal TRL clearance group(P<0.01 and 0.05).Continuing lower T and higher E_2 levels(unbalanced T/E_2 ratio) were presented 3 and 8 h postprandially(P<0.01 and 0.05).There were no significant differences in plasma PRL,LH,and FSH during fasting and 3 and 8 h postprandially(P>0.05).Conclusion The delayed clearance of TRL is a risk factor,and unbalanced T/E_2 ratio may be another risk factor for arteriosclerosis in elderly healthy men.