Solitary plasmacytoma of the mandible in a renal transplant recipient |
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Authors: | Yoon J H Yook J I Kim H J Cha I H Yang W I Kim J |
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Affiliation: | Department of Oral Pathology, College of Dentistry, Chosun University, Gwangju, Korea. |
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Abstract: | A solitary plasmacytoma occurring in the mandible of a 15-year-old Korean male 6 years after renal transplantation is reported. The tumour presented as a hyperplastic gingival overgrowth in the right madibular molar area. Histology and immunohistochemistry revealed plasmacytoma and monoclonality of the kappa chain and IgG. In situ hybridization for Epstein-Barr virus encoded RNA (EBER) showed positive signals in the tumour cells. The tumour regressed after reducing the immunosuppressive agents with concurrent radiotherapy. The patient remains in a stable condition with normal renal functions after 7 years without recurrence. This case confirms that Epstein-Barr virus associated B-lymphoproliferative disorders are still a major complication of immunosuppression. |
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Keywords: | plasmacytoma renal transplantation Epstein– Barr virus mandible. |
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