米索前列醇预防产后出血的临床观察

目的观察米索前列醇预防产后出血的效果。方法将正常足月妊娠阴道分娩者200例，随机分为试验组和对照组各100例，试验组于胎儿娩出后立即一次性口服米索前列醇400μg；对照组胎儿娩出后静脉注射缩宫素20U。结果试验组第三产程平均时间较对照组缩短4.8min,(P＜0.01)，产后2小时内平均出血量较对照组减少101.5ml，(P＜0.01)。结论米索前列醇促进子宫收缩作用强于缩宫素，能较好预防产后出血。

Clinical observation of misoprostol on prevention of postpartum hemorrhage

Objective To observe the effects of misoprostol on prevention of postpartum hemorrhage.Methods 200 cases of full-term pregnancy intravaginal labor were randomly divided into misoprostol groups (n=100) and control groups (n=100).The misoprostol groups were treated with misoprostol 400 μg PO after labor and control groups were treated with oxytocin 20 U IV after labor.Results The average time interval of the third stage was (6.10±3.35) min in misoprostol groups,whereas (10.00±3.45) min in controls.There was significant difference between two groups (P＜0.01).The average quantity of blood loss in 2 h after labor was (150.30±34.00) ml in misoprostol groups,whereas (240.60±57.30) ml in controls.Conclusion Better effects of misoprostol than oxytocin were proved on preventing postpartum hemorrhage.