甲磺酸加替沙星葡萄糖注射液治疗急性细菌性感染48例

目的 :观察甲磺酸加替沙星葡萄糖注射液治疗急性细菌性感染的有效性及安全性 .方法 :呼吸道或泌尿道急性细菌性感染的门诊或住院患者 4 8例 ,采用随机盲法对照试验 ,接受试验药甲磺酸加替沙星葡萄糖注射液或对照药盐酸左氧氟沙星注射液 2 0 0mg ,bid ,静脉滴注 ,疗程 7～ 1 4d ,评价其疗效和不良反应 .结果 :甲磺酸加替沙星葡萄糖注射液的临床有效率、细菌清除率、细菌敏感率和不良反应发生率分别为 90 .9% ,94 .7% ,1 0 0 .0 % ,1 3.6 % ;盐酸左氧氟沙星注射液为 88.5 % ,95 .4 % ,1 0 0 .0 % ,1 9.2 % .两组有效性和安全性结果经统计学分析均无显著性差异 (P >0 .0 5 ) .结论 :甲磺酸加替沙星葡萄糖注射液对一般敏感菌所致的感染具有较好的临床疗效和安全性

Treatment of acute bacterial infection with gatifloxacin mesylate glucose injection: 48 cases report

AIM: To observe the curative effect and safety of gatifloxacin mesylate glucose injection for acute bacterial infection. METHODS: Forty eight cases of acute bacteria respiratory or urinary tract infection were iv divided into two groups double blindedly and randomly. The experimental subjects of the two groups were given an injection of gatifloxacin mesylate glucose or hydrochloric acid levofloxacin 200 mg (bid) for 7 to 14 days respectively. The curative effect and the adverse reaction were evaluated. RESULTS: In experimental group, the rate of clinical curative effect, the bacterial clearance rate, the bacterial sensitivity rate and the incidence of adverse reaction were 90.9%, 94.7%, 100.0% and 13.6% respectively, and 88.5%, 95.4%, 100.0%, and 19.2% respectively in control group. There was no significant differences in the curative effect and safety between 2 groups ( P >0.05). CONCLUSION: Gatifloxacin mesylate glucose injection is clinically effective and safe for common sensitive bacterial infection.