88例早产儿动脉导管未闭的临床分析

目的 对动脉导管未闭(PDA)早产儿的临床资料进行回顾性分析，寻找和确定更适当的治疗方法。方法 88例PDA早产儿中采用消炎痛治疗59例，直接行外科手术结扎29例，对其治疗方法、出生时体重和死亡情况进行比较分析。结果 消炎痛治疗失败率为44．1％，尤其在体重小于l500g的早产儿中偏高(83．3％)，其并发症、呼吸窘迫综合征，死亡例数均较体重大于l500g的早产儿多，机械辅助呼吸时间和住ICU时间等均较长(P＜0．05)。手术患者无与麻醉或手术相关的并发症和死亡。结论 PDA早产儿的治疗应考虑以动脉导管结扎术作为首选治疗方法。

Clinical analysis of the patent ductus arteriosus in eighty-eight premature infants

Objective To find more appropriate treating method and direction with retrospective analysis of the clinical data of patent ductus arteriosus(PDA) in the premature infants. Methods Eighty-eight premature infants with PDA were treated by indomethacin (59 cases) and surgical ligation (29 cases),and comparative analyses of treatments,weight and death were made between the two groups. Results The failure rate of indomethacin therapy was 44.1%, and especially high in premature infants weighing less than 1 500g(83.3%). The complications of indomethacin therapy, respiratory distress syndrome, mechanical assisted ventilation time, intensive care unit(ICU) stay time in premature infants weighing less than 1 500g were higher than those of weighing more than 1 500g ( P <0.05). There were no failures and complications related to the operation in the surgical group. Conclusion Surgical ligation seems to be the method of choice in the management of premature infants with PDA.