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The dorsal facial area of the medulla in cats: inhibitory action of serotonin on glutamate release in regulating common carotid blood flow |
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| Authors: | Hsing-Tan Li Wen-Ying Chen Lin Liu Chung-Shi Yang Fu-Chow Cheng Chok-Yung Chai Jon-Son Kuo |
| Institution: | a Institute of Physiology, College of Life Science, Yang-Ming University, Taipei, Taiwan, ROC b Department of Education and Research and Geriatric Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan, ROC c Neurosciences Division, Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, ROC |
| Abstract: | Whether glutamate and serotonin would release and interact in the dorsal facial area (DFA) of cat medulla to regulate common carotid arterial (CCA) blood flow was explored by placing a microdialysis probe in DFA and employing high performance liquid chromatographic technique. Glutamate concentration was dose-dependently decreased by perfusion with serotonin, or alaproclate, a serotonin reuptake inhibitor. Serotonin and glutamate concentrations were increased by perfusion with KC1, a depolarizing agent. Furthermore, CCA blood flow was decreased when glutamate concentration was reduced by serotonin or alaproclate perfusion, and conversely increased when glutamate concentration was increased by KC1 perfusion. In conclusion, glutamate and serotonin releases in DFA that involve regulation of CCA blood flow are tonically mediated by nerve terminals. The glutamate release is depressed by the serotonin release. |
| Keywords: | Cerebral circulation Parasympathetic Neurotransmitter |
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