糖尿病肾病患者血清可溶性CD14水平与血糖、血脂的关系

目的探讨糖尿病肾病（DN）患者血清可溶性CD14（sCD14）水平与血糖、血脂的关系。方法将2型糖尿病（T2DM组）患者分为DN组、非DN组，采用ELISA法检测其与健康者（对照组）的血清sCD14，并分析血清sCD14水平与空腹血糖（FPG）、糖化血红蛋白（HbA1c）、肌酐（sCr）、TC、TG、HDL、LDL的关系。结果T2DM组血清sCD14、FPG、HbA1c明显高于对照组（P均〈0．01），但两组sCD14与FPG均无相关性（P〉0．05）。DN组血清sCD14水平与HbA1c、LDL呈显著正相关（β=2．89、5．26，P均〈0．05），与sCr呈显著负相关（β=-0．29，P〈0．05）；非DN组与其均无相关性（P均〉0．05）。结论血清sCD14水平与DN之间存在某些相关性，HbA1c、sCr和LDL是DN的危险因素。

Relation between the levels of serum soluble CD14 and blood glucose or lipid in patients with diabetic nephropathy

Objective To explore the correlation between the levels of serum soluble CD14（sCD14） and blood glucose or serum lipid in patients with diabetic nephropathy. Methods Patients with type 2 diabetes（T2DM group） were divided into diabetic nephropathy（DN） and non-DN group. The contents of serum sCD14 in T2DM patients and healthy controls （control group） were detected by ELISA, and then making statistical analysis of the relation between serum sCD14 and fasting plasma glucose （FPG）, HbA1c, sCr, TC, TG, HDL, LDL. Results The levels of serum sCD14, FPG and HbA1c in T2DM group were higher than those of control group（P 〈0.01 ） ,but the correlation of serum sCD14 level and FPG was no significance（P 〉 0.05）. In DN group, the level of serum sCD14 was positively correlated with HbAtc and LDL （β = 2.89,5.26 ,P 〈 0.05 ）, but the level of serum sCD14 was significantly negatively correlated with sCr（β = - 0.29, P 〈0.05）. However, the level of serum sCD14 and HbA1c, LDL or sCr were no relation in non-DN group（P 〉0.05）. Conclusions There is some correlation between the level of serum sCD14 and DN, HbA1c, sCr and LDL are the risk factors of DN.