芪天滴丸对大鼠实验性血栓形成和血液流变学的影响

目的 观察芪天滴丸对大鼠实验性血栓形成及血液流变学的影响.方法 大鼠口服灌胃给药芪天滴丸60、120、240mg· kg-1,每日1次,持续5d,末次给药后lh观察芪天滴丸对大鼠实验性血栓形成时间、血小板聚集率及高黏血症大鼠全血黏度及血沉和红细胞压积的影响.结果 芪天滴丸低、中、高剂量组能剂量依赖性延长动脉血栓形成时间,抑制血小板聚集,抑制高黏血症大鼠全血黏度及血沉的升高.结论 芪天滴丸具有明显抗血栓形成和改善血液流变学作用.

The Effects of the Qitian Dripping Pills on Thrombosis and Blood Rheology in Rats

Abstract] Objective:To investigate the effects of the Qitian dripping pills on blood rheology,platelet aggregation and thrombosis in rats.Method:rats were intragastric administration with the Qitian dripping pills in a dose 60,120,240 mg·kg^-1 respectively after 5 days.After 1 h of last administration,the effects of the Qitian dripping pills on thrombosis induced by electric stimulation and platelet aggregation rate induced by adenosine diphosphate (ADP) and arachidonic acid (AA) collagen (CG) were studied.Meanwhile,the effects of the Qitian dripping pills on blood rheology in the rat model of hyperviscosity blood symptom were observed.Results:the Qitian dripping pills significantly prolonged the time of thrombosis (P<0.05 or 0.01) and lowered platelet aggregation rate (P<0.05 or 0.01) in a dose-dependent fashion.Beside these,the Qitian dripping pills reduced the blood viscosity,blood sedimentation (P<0.05 or 0.01).Conclusion:The Qitian dripping pills have the effects of improving blood rheology and inhibiting platelet aggregation and thrombosis.