Efficiency of cardioplegic solutions containing L-arginine and L-aspartic acid |
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Authors: | O I Pisarenko V S Shul’zhenko I M Studneva |
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Institution: | (1) Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow |
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Abstract: | In experiments on rats we studied the effects of cardioplegic solutions with L-aspartic acid or L-arginine on functional recovery
and metabolism of isolated working heart after 40-min normothermal global ischemia and 30-min reperfusion. After reperfusion
of the hearts preventively protected with cardioplegic solution containing L-aspartic acid or Larginine, coronary flow decreased
in comparison with the initial values. As a component of cardioplegic solution, L-arginine was less efficient in recovery
of contractility and cardiac output of the hearts in comparison with L-aspartic acid. In hearts protected with L-aspartic
acid, the postischemic levels of ATP and phosphocreatine were significantly higher, and the level of lactate was significantly
lower than in hearts protected with Larginine. In comparison with L-arginine, L-aspartic acid is a more efficient component
of cardioplegic solution in protection of the heart from metabolic and functional damages caused by global ischemia and reperfusion.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 4, pp. 392–396, April, 2006 |
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Keywords: | cardioplegia L-aspartic acid L-arginine ischemia reperfusion cardiac function metabolism |
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