三七茜草复方对置铜宫内避孕器家兔血液流变学指标的影响

目的:探讨三七茜草复方(Sanqi Qiancao Recipe, SQR)治疗兔置铜宫内避孕器所致子宫异常出血的作用机制.方法:56只家兔,随机分成SQR大、中、小剂量组,吲哚美辛对照组,模型组,假手术组(手术后不放置宫内避孕器)及空白对照组(不造模),每组8只,其中前5组建立家兔置铜宫内避孕器模型.SQR大、中、小剂量组及吲哚美辛对照组分别予以SQR大、中、小剂量及吲哚美辛灌胃1周.模型组、假手术组及空白对照组则予以蒸馏水灌胃1周.治疗后测定血细胞比容,全血黏度低、中、高切变率,血浆比黏度及血沉.结果:置铜宫内避孕器家兔血细胞比容,全血黏度低、中、高切变率及血浆比黏度较空白对照组均有明显升高,差异有统计学意义(P<0.01).SQR治疗组家兔血细胞比容,全血黏度低、中、高切变率及血浆比黏度均较模型组低,差异有统计学意义(P<0.05或P<0.01).结论:改善血液流变性可能是SQR防治宫环出血病的机制之一.

Effects of Sanqi Qiancao Recipe on hemorheological parameters of rabbits with copper intrauterine device

Objective: To explore the mechanism of Sanqi Qiancao Recipe SQR in treating metrorrhagia caused by copper intrauterine device IUD in rabbits and to provide experimental evidence for preventing and treating this disease.Methods: Fifty-six rabbits were randomly divided into seven groups,which were normal control group,sham-operation group,untreated group,indomethacin-treated group,low-dose SQR-treated group,medium-dose SQR-treated group and high-dose SQR-treated group.Copper IUD insertion was operated in rabbits of the last five groups.Rabbits in the last four groups were treated orally with indomethacin and low-,medium-and high-dose SQR respectively for a week.Rabbits in the untreated group,normal control group and sham-operation group were given distilled water orally.Hemotocrit,blood viscosity at low,medium and high shear rate,plasma viscosity and blood sedimentation were examined after treatment. Results: The hemotocrit,blood viscosity at low,medium and high shear rate and plasma viscosity were higher in the untreated group than those in the normal control group with significant differences P<0.01 while those indexes in low-,medium-and high-dose SQR-treated groups were significantly lower than those in the untreated group P<0.05 or P<0.01.Conclusion: SQR can lead to a decrease in blood viscosity and improve the blood flow,which may be one of the mechanisms of SQR in treating metrorrhagia after copper IUD insertion.