干扰素联合酚妥拉明治疗儿童毛细支气管炎

目的观察干扰素、酚妥拉明联合治疗毛细支气管炎的临床疗效。方法将120例毛细支气管炎患儿随机分成观察组和对照组,每组60例。对照组予以抗感染、解痉平喘、吸氧、镇静等一般综合治疗,观察组在此基础上应用干扰素10万u.kg-1.d-1(最大剂量为100万u),肌肉注射;酚妥拉明0.1~0.3 mg.kg-1.d-1,静脉滴注,均每日1次,联合用药3 d。结果观察组喘憋消失时间、呼吸困难缓解时间、肺部啰音消失时间及住院时间均明显短于对照组(P<0.05);观察组3例出现轻微鼻塞,其他患者未见明显不良反应。结论干扰素、酚妥拉明联合治疗毛细支气管炎疗效确切。

Curative effect of interferon and phentolamine on children with bronchiolitis

Objective To observe the curative effect of interferon and phentolamine on children with bronchiolitis. Methods One hundred and twenty children with bronchiolitis were randomly divided into two groups. Sixty cases in every group. The common combined therapy of anti-infection,spasmolysis and mitigation was carried out in control group, based on this,children in observation group were treated with interferon 10 万 u · kg^-1· d^-1（the maximum dose was 100 万 u） by intramuscular injec- tion, and phentolamine 0.1 -0.3 mg · kg^-1· d^-1 by intravenously guttae, once a day, for three days. Results The extinction time of gasp,anhelation,pneumonic rattle and the length of stay（LOS） were shorter obviously in observation group than these in control group（P 〈0.05）. There were three cases with slight nasal obstruction in observation group, there was no other adverse effect in two groups. Conclusion The curative effect of interferon and phentolamine on children with bronehiolitis was preonunced.