Peripheral T-cell lymphomas. Clinico-pathologic study of 168 cases diagnosed according to the R.E.A.L. Classification |
| |
Authors: | S. Ascani P. L. Zinzani F. Gherlinzoni E. Sabattini A. Briskomatis A. de Vivo M. Piccioli G. Fraternali Orcioni F. Pieri A. Goldoni P. P. Piccaluga D. Zallocco R. Burnelli L. Leoncini B. Falini S. Tura S. A. Pileri |
| |
Affiliation: | (1) Service of Pathologic Anatomy and Unit of Hematopathology – Institute of Hematology and Clinical Oncology L. & A. Seràgnoli', Bologna University, Italy;(2) Department of Pediatric Oncology, Bologna University, Italy;(3) Institute of Pathologic Anatomy and Histopathology, Siena University, Italy;(4) Institute of Hematology, Perugia University, Italy |
| |
Abstract: | Background: One hundred sixty-eight peripheral T-cell lymphomas (PTCLs)were reviewed according to the Revised European–American Lymphoma (R.E.A.L.)Classification.Patients and methods: The cases, originally diagnosed on the basis of theUpdated Kiel Classification (UKC), were all provided with histologicalpreparations, immunophenotype, clinical information, and follow-up data. Theslides were reclassified by five observers, who integrated the R.E.A.Lcriteria with cell size measurements. The prognostic value of clinical andpathologic findings was assessed by univariate and multivariate analysis.Results: The R.E.A.L. Classification was reproducibly applied by all of theobservers. Clinically, anaplastic large cell lymphomas (ALCLs) differed fromthe remaining PTCLs by mean age (29.5 vs. 52.9 years), bulky disease(52.3% vs. 11.3%; P = 0.000), mediastinal mass (52.7% vs.32%; P = 0.004), and disease-free survival (68.0% vs.38.2%; P = 0.0001). Although each histological type displayed specificclinical aspects, PTCLs other than ALCL were basically characterised by a poorclinical outcome which was not influenced by the UKC malignancy grade. Atmultivariate analysis, the risk of a lower complete remission rate was relatedto bulky disease (P = 0.001), histologic group (non-ALCL) (P = 0.01), andadvanced stage (III–IV) (P = 0.0002).Conclusions: The present study supports the classification of T-celllymphomas proposed by the R.E.A.L. scheme. |
| |
Keywords: | anaplastic large cell lymphoma classification clinics histology immunohistochemistry peripheral T-cell lymphoma |
本文献已被 SpringerLink 等数据库收录! |
|