胺碘酮联用缬沙坦治疗阵发性房颤临床观察

目的观察口服胺碘酮联合应用血管紧张素Ⅱ受体拮抗剂（ARB）缬沙坦在阵发性心房颤动（简称房颤）复律后维持窦律的疗效及对左心房功能的影响。方法将68例阵发性房颤患者分为单纯口服胺碘酮组（对照组，34例）和胺碘酮加缬沙坦组（治疗组，34例），疗效观察12个月。结果共66例完成治疗，随访12个月，治疗1、3个月后两组左心房内径比较差异无统计学意义，但6、12个月后两组差异有统计学意义（P〈0．05），窦性心律维持6、12个月后比较差异有统计学意义（P〈0．05）。结论胺碘酮与缬沙坦联合治疗阵发性房颤维持窦性心律的疗效优于单用胺碘酮，并能延缓左心房扩大。

Effect of amiodarone combined with valsartan in treating paroxysmal atrial fibrillation

Objective To investigate the efficacy of amiodarone combined with angiotensin Ⅱ receptor antagonist （ARB） valsartan on paroxysmal atrial fibrillation and left atrial function. Methods A total of 68 patients with paroxysmal atrial fibrillation were randomly divided into two groups： simple amiodarone group （ control group, 34 cases） , amiodarone ＋ valsartan group （ stydy group, 34 cases） , they were treated for 12 months, following - up for 12 months. Results Totally 66 cases completed the treatment. The left atrium in simple amiodarone group was significantly higher than that in amiodarone ＋ valsartan group 6 - 12 months after treatment （ P 〈 0.05 ） ; the maintenance rates of 6 months, 12 months of sinus rhythm in amiodarone ＋ valsartan group were significantly higher than those in simple amiodarone group （ P 〈 0.05 ）. Conclusions Amiodarone combined with valsartan can reverse expansion of left atrium, and is more effective for transfer and maintain sinus rhythm compared with simple amiodarone treatment in patients with paroxysmal atrial fibrillation.