PTEN及Survivin在胰腺癌中的表达及意义

目的探讨胰腺癌及正常胰腺组织中FFEN和Survivin的表达及PTEN和Survivin在胰腺癌发展中的作用。方法采用免疫组化的方法检测48例胰腺癌中及15例正常胰腺组织中PETN、Survivin的表达情况。结果48例胰腺癌组织标本中PTEN、Survivin表达阳性率分别为31．3％（15／48）、77．1％（37／48），正常胰腺组织标本中PTEN、Survivin表达阳性率分别为66．7％（10／15）、0（0／15），两者比较差异有统计学意义（P〈0．05）；胰腺癌组织中PETN、Survivin的表达与患者的性别、年龄均无关（P〉0．05），与癌细胞分化程度、淋巴结转移及TNM分期有关（P〈0．05）。Survivin与PETN在胰腺癌组织中的表达呈负相关（r=-0．381，P〈0．05）。结论Survivin的异常高水平表达及PTEN的表达缺失与胰腺癌的发生、发展、转移及浸润密切相关。

Expression and significance of PTEN and Survivin in pancreatic cancer

Objective To investigate the expression of PTEN and Survivin in pancreatic cancer tissues and normal pancreatic tissues and the role of PTEN and Survivin in development of pancreatic cancer. Methods Two - pass immunhistochemistry was used to detect the expression of PTEN and Survivin in pancreatic cancer tissues of 48 patients and normal pancreatic tissues of 15 patients. Results The expressions of Survivin was significantly higher in cancer （ 77. 1% ） than those in normal tissues （0%）. The expressions of PTEN was significantly lower in cancer（31.3% ） than those in normal tissues （66. 7% ）. The expressions were correlated with carcinoma differentiation, lymph node metastasis and TNM stage in pancreatic carcinoma, and not correlated with gender and age of patients. The expression of Survivin in esophageal squamous cell carcinoma was negatively related to expression of PETN. Conclusions The abnormal high expression of Survivin and the loss of expression of PTEN are closely related to the occurrence, development, metastasis and invasion of pancreatic carcinoma.