氯沙坦治疗原发性高血压合并高尿酸血症的临床观察

目的观察氯沙坦对原发性高血压合并高尿酸血症患者的血压及血尿酸的影响。方法随机选择80例原发性高血压合并高尿酸血症患者，经过1周的洗脱期后给予氯沙坦治疗，以25mg／d为起始剂量，每周测1次血压，按血压调整剂量直至血压正常（收缩压〈140mmHg、舒张压〈90mmHg，1mmHg=0．133kPa），最大剂量100mg／d。观察期间不使用利尿剂、降尿酸药物及影响尿酸代谢的药物，治疗8周后观察用药前及用药后血压、血尿酸的变化。结果氯沙坦治疗后8周与治疗前比较，收缩压为（128±9）mmHgVS（155±15）mmHg，P〈0．05]、舒张压为（75±8）mmHgvs（98±9）mmHg，P〈0．05]明显下降、血尿酸水平显著降低（387±28）umol／LVS（456±31）umol／L，P〈0．05]。结论氯沙坦降低血压的同时能降低血尿酸，对肾脏有保护作用，适用于原发性高血压合并高尿酸血症的治疗。

Losartan treatment of essential hypertension combined with hyperuricemia

Objective To observe the effect of losartan on blood pressure uric acid in patients with essential hypertension combined with hyperuricemia. Methods Randomly seleetted 80 cases of primary hyperuricemia in patients with hypertension, after 1 week washout period given after losartan treatment to 25 mg/day starting dose, 1 week measure blood pressure, adjusted according to blood pressure dose until normal blood pressure （ systolic blood pressure 〈 140 mm Hg, diastolic blood pressure 〈 90 mm Hg, 1 mm Hg -0. 133 kPa） the maximum dose of 100 mg/d. During the observation period without the use of diuretics, uric acid lowering drugs and drugs that affect uric acid metabolism, treatment of 8 weeks after treatment before treatment and blood pressure, serum uric acid changes. Results After 8 weeks of losartan treatment compared with before treatment, systolic （ 128 ± 9 ）mm Hg vs （ 155 ± 15）mmHg, P 〈 0.05]diastolic（75 ±8）mm Hg vs （98 ±9）mm Hg, P 〈 0.05] significantly decreased, serum uric acid levels （387 ± 28） umol/L vs （456 ± 31 ） umol/L, P 〈 0. 05 ] were significantly decreased. Conclusions Losartan can lower blood pressure and reduce the blood uric acid and has a protective effect on the kidney for hypertension treatment of hyperuricemia.