| HPLC法测定复方感冒灵胶囊中对乙酰氨基酚和绿原酸的含量 |
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| 引用本文： | 夏方亮,王青青.HPLC法测定复方感冒灵胶囊中对乙酰氨基酚和绿原酸的含量[J].中国药事,2009,23(10):1009-1010. |
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| 作者姓名： | 夏方亮 王青青 |
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| 作者单位： | 1. 山东省滨州市药品检验所,滨州,256618
2. 滨州市人民医院 |
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| 摘 要： | 目的建立HPLC法测定复方感冒灵胶囊中对乙酰氨基酚和绿原酸的含量。方法用C18柱为固定相,以甲醇-水-冰醋酸（15∶85∶0.15）为流动相,流速为1.0mL·min-1,检测波长为280nm。结果对乙酰氨基酚和绿原酸进样量分别在0.6483～1.5127μg、0.0619～0.1445μg范围内呈良好的线性关系,r分别为0.9999,0.9998（n=5）,其平均回收率（n=5）分别为99.99%,99.47%,RSD分别为0.16%,1.29%。结论此方法可靠、准确、专属性强。
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| 关 键 词： | 复方感冒灵胶囊 对乙酰氨基酚 绿原酸 |
Determination of Paracetamol and Chlorogenic Acid in Fufang Ganmaoling Capsules by HPLC |
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| Xia Fangliang,Wang Qingqing.Determination of Paracetamol and Chlorogenic Acid in Fufang Ganmaoling Capsules by HPLC[J].Chinese Pharmaceutical Affairs,2009,23(10):1009-1010. |
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| Authors: | Xia Fangliang Wang Qingqing |
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| Institution: | Xia Fangliang and Wang Qingqing (The Institute for Drug Control of Binzhou City, Binzhou 256618; 1Binzhou People Hospital) |
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| Abstract: | Objective To establish an HPLC method for the determination of paracetamol and chlorogenic acid in Fufang Ganmaoling Capsules.Methods The C18 column was used.The mobile phase was consisted of methanol-water-glacial acetic acid（15∶85∶0.15）,and the detection wavelength was 280nm.Results The standard curves of paracetamol and chlorogenic acid were linear in range of 0.6483～1.5127μg（r=0.9999,n=5）,0.0619～0.1445μg（r=0.9998,n=5）,respectively,and the average recoveries were 99.99%,99.47%,respectively.Conclusions The method is reliable, accurate and specific. |
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| Keywords: | Fufang Ganmaoling Capsules paracetamol chlorogenic acid |
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