芝麻素对高脂血症大鼠血脂及脂肪肝形成的影响

目的:观察芝麻素对高脂血症大鼠血脂及脂肪肝形成的影响。方法:建立高血脂大鼠模型。予不同剂量芝麻素灌胃治疗8周后,检测大鼠血脂、脂蛋白代谢酶、脂质过氧化物、载脂蛋白及肝指数、肝脏病理变化。结果:芝麻素能显著降低模型组大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B100(ApoB100)、丙二醛(MDA)含量和肝指数,升高高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、肝酯酶(HL)活性(P<0.05);并使脂肪肝损伤得到明显改善。结论:芝麻素具有调脂和防治脂肪肝的作用,可能与调节脂质代谢及抗氧化作用等有关。

Effects of Sesamin on Lipidemia and Non-alcoholic Steatohepatitis in Hyperlipidemia Rats

Objective: To investigate the effects of sesamin on lipidemia and the formation of non-alcoholic steatohepatitis(NASH).Methods: Hyperlipidemia rats model were established by feeding high lipid diet.The liver index,total cholesterol(TC),triglyeeride(TG),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),lipoprotein lipase(LPL),hepatic lipase(HL),apoproteinA1(ApoA1),apoproteinB100(ApoB100),superoxidedismutase(SOD)and malonaldehyde(MDA) were measured after administration with sesamin for 8 weeks.As well as,livers were taken for histopathological examination.Results: Therapeutic groups were significantly decreased TC,TG,LDL-C,ApoB100,MDA and liver index,increased HDL-C,HL,SOD(P<0.05).The fatty degeneration and steatosis in liver were ameliorated by sesamin.Conclusion: Sesamin can remarkably modulate lipidemia and cure the NASH.Its mechanism is probably mediated through regulating lipids metabolism and anti-oxidation.