| 肺纤方对特发性肺间质纤维化患者血清基质金属蛋白酶1、2及其抑制剂的影响 |
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| 引用本文： | 张晓梅,姜良铎,尹婷,张伟,吴建军.肺纤方对特发性肺间质纤维化患者血清基质金属蛋白酶1、2及其抑制剂的影响[J].中华中医药杂志,2009(6). |
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| 作者姓名： | 张晓梅 姜良铎 尹婷 张伟 吴建军 |
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| 作者单位： | 北京中医药大学东方医院;北京中医药大学东直门医院;北京王府医院; |
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| 基金项目： | 2004-2007年北京科委资助课题(No.Y0204003041011) |
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| 摘 要： | 目的:观察肺纤方治疗特发性肺间质纤维化的疗效和对患者肺基质重塑的影响。方法:将40例特发性肺间质纤维化患者随机分为治疗组20例、对照组20例,治疗组给予中药肺纤方治疗,对照组给予激素泼尼松治疗,疗程均为3个月。观察治疗后的临床疗效和患者血清基质金属蛋白酶1、2及其抑制剂的变化。结果:治疗组总有效率为84.2%,对照组总有效率为81.3%,肺纤方组治疗后能显著降低患者血清基质金属蛋白酶1、2及其抑制剂。结论:肺纤方能有效治疗特发性肺间质纤维化可能与其抑制患者肺基质重塑有关。
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| 关 键 词： | 特发性肺间质纤维化 肺纤方 基质金属蛋白酶1、2 组织金属蛋白酶抑制剂1、2 |
The effect of Feixian Fang treating the idiopathic pulmonary fibrosis patients in MMPs and TIMPs |
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| ZHANG Xiao-mei,JIANG Liang-duo,YIN Ting,ZHANG Wei,WU Jian-jun.The effect of Feixian Fang treating the idiopathic pulmonary fibrosis patients in MMPs and TIMPs[J].China Journal of Traditional Chinese Medicine and Pharmacy,2009(6). |
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| Authors: | ZHANG Xiao-mei JIANG Liang-duo YIN Ting ZHANG Wei WU Jian-jun |
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| Institution: | ZHANG Xiao-mei1,JIANG Liang-duo2,YIN Ting1,ZHANG Wei2,WU Jian-jun3 (1 Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China,2Dongzhimen Hospital,Beijing 100700,3 Beijing Wangfu Hospital,Beijing 102209,China) |
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| Abstract: | Objective:To research the therapeutic effect dnd pulmonary ground substance rebuilding in the treatment on IPF patients by Feixian-Fang and.Methods:Treatment 20 cases IPF by Feixian Fang RCT prednisone three months.obsive The therapeutic efficacy and the levels of matrix met alloproteinase 1,2,tissue inhibtor of met alloproteinase(TIMP-1,2).Results: The total effective rate of Feixian-Fang group is 84.2%.The total effective rate of prednisone group is 81.3%.Feixian-Fang can reduce the level of MMP-1,MMP-2,T... |
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| Keywords: | IPF Feixian-Fang MMP-1 MMP-2 TIMP-1 TIMP-2 |
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