| 黄芪多糖、人参茎叶皂甙对创伤小鼠淋巴细胞膜流动性及淋巴细胞功能的影响 |
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| 引用本文： | 粱华平 王正国 耿坡 田丰群. 黄芪多糖、人参茎叶皂甙对创伤小鼠淋巴细胞膜流动性及淋巴细胞功能的影响[J]. 中药药理与临床, 1996, 12(3): 15-18 |
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| 作者姓名： | 粱华平 王正国 耿坡 田丰群 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所 |
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| 摘 要： | 小鼠腹腔注射黄芪多糖（ＡＰＳ）２５０ｍｇ／ｋｇ·ｄ、皮下注射人参茎叶皂甙（ＧＳＬ）５０ｍｇ／ｋｇ·ｄ连续４天，可明显对抗创伤小鼠脾细胞、胸腺细胞、肠系膜淋巴结细胞膜流动性的降低，提高Ｔ细胞质膜、线粒体膜、微粒体膜的流动性，改善Ｔ细胞白介素２（ＩＬ－２）ｍＲＮＡ、ＩＬ－２受体（ＩＬ－２Ｒ）ｍＲＮＡ、ＩＬ－２、ＩＬ－２Ｒ、Ｔ淋巴细胞转化（ＴＬＴ）的受抑状态。表明ＡＰＳ、ＧＳＬ可提高创伤后淋巴细胞膜的流动性，增强淋巴细胞的功能。
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| 关 键 词： | 黄芪多糖；人参茎叶皂甙；创伤；淋巴细胞；膜流动性 |
Effects of Astragalus Polysaccharides, Ginsenosides of Stem and Leaf on LymphocyteMembrane Fluidity and Lymphocyte Function in Traumatized Mice |
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| Liang Huaping, Wang Zhengguo, Geng Bo, Tian Fengqun. Effects of Astragalus Polysaccharides, Ginsenosides of Stem and Leaf on LymphocyteMembrane Fluidity and Lymphocyte Function in Traumatized Mice[J]. Pharmacology and Clinics of Chinese Materia Medica, 1996, 12(3): 15-18 |
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| Authors: | Liang Huaping Wang Zhengguo Geng Bo Tian Fengqun |
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| Abstract: | ither intraperitoneous administration of astragalus polysaccharides (APS) at dosage of 250 mg /kg. d 4 d or sub-cutaneous admimistration of ginsenosides of stem and leaf (GSL)at dosage of 50mg/kg. d 4d could resist significant-ly the reduction of membrane fluidity of lymphocytes from spleen, thymus, mesenteric lymph nodes in traumatizedmice, elevate membrane fluidity of T cell plasmalemma, mitochondria membrane and microsome membrane, alleviatethe suppression of interleukin 2 (IL- 2) InRNA, IL-2 reCeptor (IL-2R) mRNA, IL- 2, IL-2R, T lymphocytetransfomation (TLT). It is suggested that APS and GSL can elevate lymphocyte membrane fluidity, enhance lympho-cyte function after trauma. |
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| Keywords: | astragalus polysaccharides ginsenosides trauma lymphocyte membrane fluidity |
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