膜增殖性肾小球肾炎9例临床病理分析

目的:分析9例经肾穿刺活检诊断为膜增殖性肾炎患者临床及病理特点,提高对该病临床及病理诊断方面的认识。方法:回顾1998年9月~2008年9月237例肾穿刺活检病例中诊断为膜增殖性肾小球肾炎9例患者,对其临床表现、光镜病理、电镜病理、免疫荧光病理特点进行总结和分析。结果:9例膜增殖性肾小球肾炎患者占肾穿刺活检总病例数的3.7%,男女性别比为8∶1。年龄最小为18岁、最大57岁,平均年龄为39.3岁。以肾病综合征伴血尿、高血压为其主要临床特点。平均随访时间25个月。部分缓解3例,无效2例,恶化4例(进入透析)。结论:膜增殖性肾炎是一种发病率不高的肾小球疾病。临床主要表现为肾病综合征伴肾炎综合征,病理表现有其特殊性。

Clinical Pathology Analysiy of 9 Cases of Membranoproliferative Glomerulonephnitis

Objective:Analyze clinical manifestations and pathological features of nine patients which have fallen clown with Membranoproliferative Glomerulonephnitis(MPGN)depending on a Kidney biopsy in order to improve clinical and pathological diagnosis.Methods:A review of 9 cases with MPGN diagnosed througn a kidney biopsy among 237 cases from September,1998 to September,2008.To sum up clinical manifestations,their light microscopy pothologies,electron miscroscopy pathologles and immunofluorescence pathologies to analyzed.Results:9 cases of MPGN was 3.7% among 237 cases diagonsed by a kidney biopsy Male to female was 8 to 1.The youngest pationt was 18 years old,The oldest one was 57 nyears old,Patients' average age was 39.3 years old,The mainfeature is Nephrotic Syndrome with hematuria and high blood pressure,The average follow-up period was 25 months Partial remission was 3 cases,inefficiency was 2 cased,deteriorationwas 4 cases.Conclusion:MPGN was a low incidence of renal glomerular disease,The main clinical manifestation was Nephrotic Syndrom a campamied bynephiritic syndrome.Its pathological manifestation had its own specificness.