| 川芎嗪对糖尿病大鼠视网膜保护作用的机制 |
| |
| 引用本文： | 黄焱,陈少强,陈瑞华,张更.川芎嗪对糖尿病大鼠视网膜保护作用的机制[J].中药药理与临床,2002,18(5):18-20. |
| |
| 作者姓名： | 黄焱 陈少强 陈瑞华 张更 |
| |
| 作者单位： | 福建医科大学人体解剖学教研与组织胚胎学系,福州,350004 |
| |
| 基金项目： | 本课题为福建省自然科学基金资助课题,编号:c9810034 |
| |
| 摘 要： | 目的 :探讨川芎嗪对糖尿病性视网膜病防治作用的机理。方法 :用链脲佐菌素 (STZ)制作糖尿病大鼠动物模型 ,分为正常对照组、糖尿病对照组、糖尿病川芎嗪治疗组 ,于第 12周测定各组大鼠视网膜组织NOS和AR活性 ,用免疫组化方法观察其VEGF表达的变化。结果 :川芎嗪治疗组大鼠视网膜组织NOS和AR活性、VEGF的表达显著低于糖尿病对照组。结论 :川芎嗪能够抑制糖尿病大鼠视网膜组织NOS和AR活性 ,减少VEGF的表达 ,从而对糖尿病性视网膜病起防治作用。
|
| 关 键 词： | 川芎嗪 糖尿病视网膜病 醛糖还原酶(AR) 一氧化氮合酶(NOS) 血管内皮细胞生长因子(VEGF) |
Protective mechanism of TMP on the retinal tissue of diabetic rats |
| |
| Huang Yan,Chen Shaoqiang,Chen Ruihua,Zhang geng.Protective mechanism of TMP on the retinal tissue of diabetic rats[J].Pharmacology and Clinics of Chinese Materia Medica,2002,18(5):18-20. |
| |
| Authors: | Huang Yan Chen Shaoqiang Chen Ruihua Zhang geng |
| |
| Abstract: | Object: To investigate the protective effect of Tetramethylprazine (TMP) on diabetic retinopathy and explore its possible mechanism. Method: After 12 weeks the activities of retinal tissue nitric oxide syntheses (NOS) and aldose reductase (AR) was determined in streptozotocin-induced diabetic rats, which were divied into normal control group (N group). diabetes control group (DM group) and TMP-treated group (T group). The positive expression of VEGF (vascular endithelial growth factor) in retina of each group was observed by immunohistochemical staining. Result: The positive expression of VEGF in retina and the activities of NOS and AR in retina of the T group rats was weaken significantly compared with the DM group, but still above normal level. Conclusion: TMP may prevent the development of diabetic retinopathy, and the effect may be partly achieved by repression the VEGF and restrained the activities of retinal NOS and AR. |
| |
| Keywords: | tetramethylprazine diabetic retinopathy aldose reductase nitric oxide synthase vascular endithelial growth factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
