Increases in pulmonary artery pressure and cardiac output due to the inhibition of nitric oxide synthesis during operative stress |
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| Authors: | Koji Sasajima Masahiko Onda Masao Miyashita Kei-ichi Ohkawa Takeshi Matsutani Yukihiro Akiya Shinhiro Takeda Ryo Ogawa Yukiko Kurashima Hiroyasu Esumi |
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| Affiliation: | (1) First Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113 Tokyo, Japan;(2) Department of Anesthesiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113 Tokyo, Japan;(3) Biochemistry Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104 Tokyo, Japan |
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| Abstract: | Pulmonary artery pressure (PAP), cardiac output (CO), and urinary nitrate, a stable endproduct of nitric oxide (NO), were measured pre- and postoperatively in eight patients who underwent esophagectomy for squamous cell carcinoma of the thoracic esophagus. A significant elevation of PAP and CO on the day of operation (POD 0) was accompanied by a low concentration of urinary nitrate. A reduction in PAP and CO, and an increase in nitrate to the preoperative levels, were found on PODs 2 and 3, respectively, but urinary nitrate decreased again after POD 3. Consequently, the changes in PAP and CO were closely correlated with the nitrate concentration. These results suggest that operative stress inhibited NO synthesis with a transitory induction of endogenous NO synthesis postoperatively. |
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| Keywords: | nitric oxide urinary nitrate operative stress |
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