| 新一代人工牛黄的药理与毒理学研究 V.对呼吸系统的影响 |
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| 引用本文： | 徐秋萍,李华,吴金英,孙建宁,唐元泰,潘善庆,袁惠南,林飞.新一代人工牛黄的药理与毒理学研究 V.对呼吸系统的影响[J].中国生化药物杂志,1994(2). |
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| 作者姓名： | 徐秋萍 李华 吴金英 孙建宁 唐元泰 潘善庆 袁惠南 林飞 |
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| 作者单位： | 北京中医学院药理室!北京100029(徐秋萍，李华，吴金英，孙建宁)，天津市药品检验所(唐元泰)，湖南省药品检验所(潘善庆)，中国药品生物制品检定所(袁惠南，林飞) |
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| 摘 要： | 本文比较研究了新一代人工牛黄、老人工牛黄和天然牛黄对呼吸系统的影响.结果显示:麻醉猫灌胃给药2g/kg,给药后观察120min,正常家兔静脉给药5mg/kg和15mg/kg,给药后观察15min,对呼吸频率和呼吸深度均无明显影响.在Ach所致高体豚鼠气管痉挛时,新一代人工牛黄Ⅰ有明显解痉作用.小鼠酚红法实验发现:各种牛黄灌胃0.3 g/kg和1.0g/kg时均有明显祛痰作用.二氧化硫引咳实验显示,仅有灌胃1g/kg的天然牛黄有明显镇咳作用.
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| 关 键 词： | 人工牛黄 天然牛黄 呼吸深度和呼吸率 祛痰 镇咳 |
Pharmacological and Toxicological Studies of New Artificial Niuhuangs V. Effects on Respiratory System |
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| Xu Qiuping,Li Hua,Wu Jinying,Sun Jianning,Tang Yuantai,Pan Shanqing,Yuan Huinan,LinFei.Pharmacological and Toxicological Studies of New Artificial Niuhuangs V. Effects on Respiratory System[J].Chinese Journal of Biochemical Pharmaceutics,1994(2). |
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| Authors: | Xu Qiuping Li Hua Wu Jinying Sun Jianning Tang Yuantai Pan Shanqing Yuan Huinan LinFei |
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| Institution: | Beijing 100029 |
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| Abstract: | In this paper the compare effects of new and old artificial Niuhuangs with natural Ni-uhuangs on respiratory system are reported. The results showed no apparent effects on respiratory frequency and depth until 120 min ig 2 g/kg dose to anesthetized cats, 15 min iv 5 mg/kg and 15 mg/kg to normal rabbits. New artificial Niuhuang I has apparent anticramps action on cramps induced by Ach in isolated broch of guinea pig. We have found that these Niuhuangs have obvious expectorant action using phenal red method in mice. The experiment of cough induced by SO2 showed that only natural Niuhuang at ig 1 g/kg has apparent antitussive action. |
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| Keywords: | Artificial Niuhuang Natural Niuhuang Respiratory frequency and depth Expectorant action Antitussive action |
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