| Expression of Angiopoietin-2 Gene and Its Receptor Tie2 in Hepatocellular Carcinoma |
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| 作者姓名： | 陈立波 杨镇 王国斌 王春友 |
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| 作者单位： | CHEN Libo，YANG Zhen *，WANG Guobin，WANG Chunyou Department of General Surgery，Xiehe Hospital，Tongji Medical School，Huazhong University of Science and Technology，Wuhan 430022 Department of General Surgery，Tongji Hospital，Tongji Medi |
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| 摘 要： | The relationship of angiogenesis and solid tumoris one hot spot in tumor researching field.Tumor isconsisted of tumor cells and vessels. Tumor inducesand promotes angiogenesisand vice versa. Angiogen-esis promotes tumor development and provides path-ways for tumor metastasis1,2 ] .Anti- angiogenesis isconsidered one potent anti- tumor therapy. Hepato-cellular carcinoma( HCC) is characteristic of highblood infusion,high vascular metastasis and recur-rence. Angiogenesis may play an important …
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| 收稿时间： | 28 April 2001 |
Expression of angiopoietin-2 gene and its receptor Tie2 in hepatocellular carcinoma |
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| Chen Libo,Yang Zhen,Wang Guobin,Wang Chunyou.Expression of Angiopoietin-2 Gene and Its Receptor Tie2 in Hepatocellular Carcinoma[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2001,21(3):228-230. |
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| Authors: | Chen Libo Yang Zhen Wang Guobin Wang Chunyou |
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| Institution: | (1) Department of General Surgery, Xiehe Hospital, Tongji Medical School, Huazhong University of Science and Technology, 430022 Wuhan;(2) Department of General Surgery, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, 430030 Wuhan |
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| Abstract: | Summary To explore the relationship of angiogenesis-related angiopoietin-2 gene and its receptor Tie2 with angiogenesis and the biology,
of hepatocellular carcinoma (HOC), angiopoietin-2 gene, Tie2 and CD34 protein expression in 22 resected HOC, 8 cirrhotic and
8 control liver specimens were investigated byin situ hybridization and immunohistochemistry respectively, and the level of angiopoietin-2 and Tie2 expression in HCC were compared
in terms of tumor biological parameters. It was found that CD34 was not expressed in control liver, expressed scarcely in
cirrhotic liver (17. 8±13.5/HP), but intensively expressed in HCC (86. 3±34. 8/HP,P<0.01). Tie2 receptor was not expressed in controls, expressed at low level in cirrhotic liver (11. 3±8.7/HP), while strongly
positive in the microvascular endothelia of HCC (52. 4±16. 7/HP,P<0.01). The level of Tie2 receptor expression in HCC was closely related with tumor diameter, angiogenesis and portal invasion.
Angiopoietin-2 gene was not expressed in control liver, expressed mildly in cirrhotic liver (11.2±9. 7/HP), but extensively
in tumor zone (36. 4±17. 5/HP), the level of angiopoietin-2 expression was closely related with angiogenesis, portal invasion
and histological grading of HCC. It is concluded that angiogenesis is increased in HCC; angiopoietin-2/Tie2 expression in
human hepatic carcinoma is closely related with angiogenesis, which are probably involved in the HCC angiogenesis regulation,
promoting the development and metastasis of human hepatic cancer. |
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| Keywords: | angiopoietin-2 Tie2 receptor angiogenesis carcinoma hepatocellular |
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